MAPT and Mental deterioration: For example, SAMP8 has shown passive and active avoidance responses indicative of memory impairment and cognitive decline at 2 months, followed by tau hyperphosphorylation at 3 months, inflammation at 5 months, Aβ deposition at 6 months, synaptic degeneration at 8 months, and neuronal loss at 10 months [136].