Depletion of Rbfox3 staining in subsets of neurons that appear normal (not ischemic-necrotic, apoptotic, or continuum) by Nissl staining in the piglet somatosensory cortex could be biochemically and functionally tantamount to somatic de novo loss-of-function mutations in the Rbfox3 gene in neocortical neuron ensembles with altered excitability and function caused by exonic “poisons,” as in Dravet syndrome [151]. Here, RBFOX3 is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.