Here, we assessed changes in the cav-1 oligomer/monomer ratio under different treatment conditions, as shown in Figure 8C. A remarkable decrease (~5-fold) in the oligomer/monomer ratio was observed in response to OB-T2D adiposomes, and this was entirely reversed by pretreatment with L-NAME or PP2 (Figure 8C). Here, CAV1 is linked to type 2 diabetes mellitus.