For example, a recent study aimed at determining whether age affects different cell types in NVU resulted in the model discriminating Alzheimer’s disease (AD) from healthy control (HC) samples, revealing 15 genes related to accelerated aging (AAG): IGF1R, MXI1, RB1, PPARA, NFE2L2, STAT5B, FOS, PRKCD, YWHAZ, HTT, MAPK9, HSPA9, SDHC, PRKDC and PDPK1 [42]. This evidence concerns the gene NFE2L2 and Alzheimer disease.