For example, a recent study aimed at determining whether age affects different cell types in NVU resulted in the model discriminating Alzheimer’s disease (AD) from healthy control (HC) samples, revealing 15 genes related to accelerated aging (AAG): IGF1R, MXI1, RB1, PPARA, NFE2L2, STAT5B, FOS, PRKCD, YWHAZ, HTT, MAPK9, HSPA9, SDHC, PRKDC and PDPK1 [42]. The gene discussed is MAPK9; the disease is Alzheimer disease.