ALK and lung cancer: There were no additional mutations in K-Ras, and none of the other known major oncogenes (Egfr, B-Raf, Alk, Mek, Stk11, Smarca4, and Pi3ka) or tumor suppressors (Rb1, Apc, and p53) involved in lung cancer were mutated in any of the ADCs (Figure 3B and Supplementary Data S1).