There were no additional mutations in K-Ras, and none of the other known major oncogenes (Egfr, B-Raf, Alk, Mek, Stk11, Smarca4, and Pi3ka) or tumor suppressors (Rb1, Apc, and p53) involved in lung cancer were mutated in any of the ADCs (Figure 3B and Supplementary Data S1). This evidence concerns the gene APC and lung carcinoma.