Notably, a significant upregulation of TP53 and the histone-modifying enzymes SUV39H1, EZH2, PRMT1, HDAC8, and KDM5B, along with the upregulation of DNA methyltransferase DNMT3A and ubiquitin ligase UHRF1 mRNA levels was detected in ACC tissues with downregulation of lysine acetyltransferase KAT2B levels. Here, HDAC8 is linked to adrenal cortex carcinoma.