The PPI network indicates a significant upregulation of the TP53 gene in ACC neoplasms interacting with several histone-modifying enzymes, such as the lysine methyltransferases SUV39H1 and EZH2, the protein arginine methyltransferase 1 PRMT1, the lysine demethylase KDM5B, and the histone deacetylase HDAC8. The gene discussed is EZH2; the disease is adrenal cortex carcinoma.