Following the transcriptional data analysis, we proceeded to evaluate the protein expression levels of p53 and histone-modifying enzymes SUV39H1, EZH2, and HDAC8 in 10 tissues of salivary gland tumors, including 2 pleiomorphic adenomas, PA, 3 polymorphous adenocarcinomas, PAC, and 5 adenoid cystic carcinomas, ACC. This evidence concerns the gene TP53 and adenoma.