CDKN2A and adrenal cortex carcinoma: DNA methylation of cyclin-dependent kinase inhibitors (CKI) and p27, p21, p19, p18, and p15 genes is frequently observed in ACCs, being considered as an early event in tumor development [19], while the methylation of RARb2 and RASSF1 and promoter hypermethylation of p16(INK4A) have been associated with ACC pathogenesis [5].