For example, some research focused on the bioinformatic analysis of genes, and pathways differentially expressed in IPF through the analysis of public databases identified TNC, CDH2, FBN1 and SPP1 as some of the main DEGs with the highest significant upregulation in samples from patients with IPF compared to their respective controls [16,42,43,44]. This evidence concerns the gene SPP1 and idiopathic interstitial pneumonia.