This hub gene profile (TNC, CDH2, APOE, SPP1, SERPINA1, FBN1, IL6, FN1, CYR61, and TF) can be considered an important target to investigate its relationship with the molecular mechanisms associated with IPF development and to evaluate it as a candidate diagnostic and prognostic biomarker. This evidence concerns the gene SPP1 and idiopathic interstitial pneumonia.