This hub gene profile (TNC, CDH2, APOE, SPP1, SERPINA1, FBN1, IL6, FN1, CYR61, and TF) can be considered an important target to investigate its relationship with the molecular mechanisms associated with IPF development and to evaluate it as a candidate diagnostic and prognostic biomarker. Here, FBN1 is linked to idiopathic interstitial pneumonia.