On the other hand, recent studies have reported that microfibrils isolated from the skin of Tsk−/− mice, a model of systemic sclerosis, maintain a statistically significant increase in fibrillin-1 and are associated with the upregulation of a prooxidant phenotype in endothelial cells, thus facilitating their activation and mesenchymal transition [63]. The gene discussed is FBN1; the disease is systemic sclerosis.