Moreover, the results obtained showed that CDH2, SPP1, and TNC maintained a statistically significant increase associated with the progression of individual cancer stages, and it was observed that the downregulation in CYR61, SERPINA1, and IL6 expression maintained a statistically significant association with the progression of individual cancer stages in LUSC tumor samples compared to their respective controls (Figure 11B). This evidence concerns the gene SERPINA1 and cancer.