In this context, NPAS2 is relevant in psychiatric disorders associated with deranged reward sensibility and highly expressed in reward-related brain regions, particularly in the mammalian forebrain, comprising the NAc, a key hub in the control of behavior linked to motivation and recompense, as well as dopamine receptor 1 containing medium spiny neurons (D1R-MSNs) of the striatum. Here, NPAS2 is linked to psychiatric disorder.