FLT3 and leukemia: Our findings revealed heterogeneous sorafenib sensitivity across different leukemia cell lines, with the highest resistance scores observed in U937, HL60, Jurkat, and FLT3-ITD mutation patients with sorafenib resistance and the lowest scores in MV4-11, MOLM13, K562, and THP-1 (Figure 3a,b, Supplementary Figure S2a,b).