The association of dysregulated miRNAs with target mRNAs that are involved in steatosis (lipid pathways, SREMP, ACOX3, HMGCR and LCLAT1), particularly triglyceride metabolism (PNPLA3, ATGL ABDH and FAF2) supports the new understanding that lipids play a key role in this disease pathogenesis and miRNAs may regulate this pathway, contributing to the underlying molecular mechanisms of lipid genetics in alcohol-associated cirrhosis. The gene discussed is PNPLA2; the disease is Cirrhosis.