Interestingly, astrocyte-specific TDP-43 M337V expression led to a progressive depletion of the astrocytic glutamate transporters EAAT1 and EAAT2, and induced the expression of lipocalin-2 (lcn2) [160], a neurotoxic factor released by reactive astrocytes that is increased in the post-mortem ALS motor cortex and spinal cord [161]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.