TWIST1 and neoplasm: Together, DYRK2 as a tumor suppressor may induce apoptosis by inducing p53-Ser46 phosphorylation; cleaved PARP and caspase 3; the suppression of c-Myc, Cyclin D1 and D2, and Ki-67 expression; the inhibition of cell migration and invasion by regulating E-cadherin, Snail, Twist, and miR-622 expression; and the regulation of DNA methylation by DNMT1 expression (Figure 1).