KLF4 and neoplasm: Taken together, DYRK2, as a tumor suppressor, may induce apoptosis by c-Jun, c-Myc, and HSF1 phosphorylation and inhibit cell stemness by suppressing the CD44+/CD24− subpopulation and KLF4 and TERT expression via AR; cell proliferation via the suppression of CDK14 expression; and the regulation of EMT, invasion, and metastasis through the Snail phosphorylation and induction of mTOR degradation (Figure 5).