KLF4 and chronic myelogenous leukemia, BCR-ABL1 positive: DYRK2 levels are low in chronic myeloid leukemia (CML) cell lines (K562, KU-812, and KBM5), whereas DYRK2 expression is high in hematopoietic stem cells (lineage-negative Sca-1+ c-Kit+ (LSK) cells) from Krüppel-like factor 4 (KLF4) knockout mice [12].