Under standard conditions (37 °C), melanoma cells were characterized by a high level (>0.04) of HSPD1 (HSP60), HSPA8 (HSP70), and HSP90AB1 (HSP90), and a medium level (0.02–0.04) of HSPB1 (HSP27), HSPA9 (HSP70), and AHSA1 (HSP90). This evidence concerns the gene HSPB1 and melanoma.