Interestingly, an increase in HSP27 expression was observed after exposure to a higher temperature in all melanoma cells: HSPB1 (A375 and G-361), and HSPB6 (SK-MEL-1) and HSP40: DNAJC4 (A375, G-361, and SK-MEL-1). This evidence concerns the gene HSPB6 and melanoma.