VEGFA and cancer: In addition, the enrichment analysis of the KEGG pathway showed that the 21 CRGs were mostly associated with ubiquitin–mediated proteolysis, protein processing in the endoplasmic reticulum, shigellosis, pathways of neurodegeneration–multiple diseases, central carbon metabolism in cancer, the HIF–1 signaling pathway, chemical carcinogenesis–reactive oxygen species, and the VEGF signaling pathway (Figure 3B).