In the comparison of differentially expressed genes between tumor and normal tissues in LUAD patients from the GSE10072 dataset and TCGA, the genes AOC1, ATOX1, CCL8, CCS, COX11, CP, LOXL2, MAP2K2, PDK1, SCO2, SOD1, UBE2D1, UBE2D3, and VEGFA showed significantly higher expression in LUAD tissues while ATP7B, DβH, PDE3B, SLC31A2, UBE2D2, UBE2D4, and ULK2 showed lower expression compared to normal tissues (Figure 2A–C, Supplementary Table S1). Here, PDE3B is linked to neoplasm.