NKA activity decreases in necropsy materials from ischemic heart and animal models of heart disease [31,32,33,34,35], which causes elevated intracellular Na+, increased activities of Na+/H+ and Na+/Ca2+ exchangers, intracellular Ca2+accumulation, deterioration of diastolic function, arrhythmias, and compromised cell metabolism [36,37,38,39]. Here, TAC1 is linked to heart disorder.