The results showed irradiation with a dose of 6 Gy and transfection with SAE1 siRNA, both induced CRC apoptosis, and the apoptosis percentage of the SAE1 siRNA + 6 Gy group was higher than that of the other two groups in HCT116 (Figure 8B) and SW620 (Figure 8B) cells. The gene discussed is SAE1; the disease is colorectal carcinoma.