MKI67 and breast carcinoma: Several studies suggest PROP’s anticancer mechanism involves decreasing pro-proliferative Ki-67 and pro-survival Bcl-2 markers, disrupting cell cycle progression, altering cyclin levels, elevating p53, enhancing caspase cleavage, and inducing apoptosis, as demonstrated in breast cancer cases and other tumor types [79,80,81,82,83,84].