This damaging activity of the endothelial barrier is also linked to the hyperactivation of the renin–angiotensin–aldosterone system promoted by hyperglycemia since the MAP kinase (MAPK) system is a signal transduction pathway common to insulin and aldosterone and its activation induces proliferation and contractility of vascular myocytes and proinflammatory activity of endothelial cells [85,86,87]. The gene discussed is INS; the disease is Hyperglycemia.