SSc-ILD was particularly associated with anti-topoisomerase I antibodies (anti-Scl-70 antibody), antinuclear antibodies with nucleolar pattern (including anti-RNA-polymerase III, anti-NOR-90 anti-Th/To, anti- PM/Scl-75, anti-U3-RNP/fibrillarin or anti-PM/Scl-100 antibodies) [81,82,83,84,85,86,87]. The gene discussed is FBL; the disease is systemic sclerosis.