The biomarkers most associated with active lung disease and progression specifically in SSc-ILD are KL-6 (Krebs von den Lungen-6), SP-D (surfactant protein), C-reactive protein, and CCL19 although other biomarkers are also present non-specific can be elevated [81,82,83,84,85,86,87]. This evidence concerns the gene MUC1 and interstitial lung disease.