In their interesting study Michalska-Jakubus et al. suggested for the first time that dysregulation of angiopoietins/VEGF system with shift towards Ang2 and VEGF and decrease in Ang1 levels may play a role in progression of SSc specific microangiopathy from capillary enlargement and collapse to aberrant vessel repair and final loss of angiogenesis [12]. This evidence concerns the gene VEGFA and systemic sclerosis.