Cytokeratin 17 (CK17), marginal zone protein B1 (MZB1), and leucine-rich α2-glycoprotein-1 (LRG1) appear to be potential biomarkers for SSc, with CK17 negatively associated with disease severity and higher values of CK17 protective [37,59,60,61,62,63,64,65,66,67]. This evidence concerns the gene KRT17 and systemic sclerosis.