Overexpression of type I IFN, TGF-β, PPAR-γ, PI3K-Akt, as well as serum levels of adiponectin, MMP-9, MMP-12, LOX, ADAM12, THBS1, COMP could be used as potential biomarkers of SSc-related skin fibrosis [40,41,42,43,44,45,46,47,76,77,78,79,80,81,82,83,84,85,86,87]. This evidence concerns the gene COMP and systemic sclerosis.