TYROBP and chronic kidney disease: Supporting this hypothesis, previous researches described the clinical role of TREM-1 in the development and aggravation of acute or chronic kidney diseases: TREM-1 was identified to participate in the pathogenesis of acute kidney disease using a TREM-1 inhibitor [35]; meanwhile, TREM-1 along with DAP12 was involved in macrophage polarization, leading to mediating tubular injury and interstitial fibrosis in obstructive nephropathy [36,37].