First of all, m6A has been well-studied for its role in cancer, and the deposition in RNA are mainly mediated by a methyltransferase (i.e., Writers) complex, including METTL3, METTL14, WTAP, KIAA1459/VIRMA, ZC3H13, HAKAI and RBM15/15B, or METTL16 under existence of SAM. Here, METTL3 is linked to cancer.