Towards the end of the fourth cycle, there were elevations in gonadotrophins to menopausal ranges [FSH: 42.3 (menopausal reference range: 22 – 153 U/L); LH: 36.2 (menopausal reference range: 11 – 40 U/L)], with undetectable estradiol levels (<5 pg/mL; normal menopausal value: <10 pg/mL) suggestive of early menopause (onset of menopause at age <45 years) due to hypergonadotropic hypogonadism. This evidence concerns the gene PLOD1 and Hypergonadotropic hypogonadism.