The inflammatory factors [C-X-C Motif Chemokine Ligand 8 (CXCL8), CXCL2, and matrix metalloproteinase 9 (MMP9)] were significantly increased and the lipid metabolism regulators (Apolipoprotein B (APOB) and Cholesteryl ester transfer protein (CETP)) were significantly decreased in patients with obesity. Here, CXCL8 is linked to obesity due to melanocortin 4 receptor deficiency.