CRB1 and Leber congenital amaurosis: Approximately 7%–17% of LCA and 3%–9% of RP patients are reported with mutations in CRB1. 10,11,12 RP is a clinically and genetically heterogeneous disease where children or aged patients experience night blindness that progresses to complete loss of vision,13 while LCA causes visual impairment in newborns.14