In this study, we have shown that the complete loss of CRB1 in human CRB1KO and CRB1KOCRB2+/− retinal organoids results in degeneration of the inner and outer retina, whereas CRB1 RP patient-derived retinal organoids carrying a missense mutation showed strongly reduced levels of variant CRB1 and degeneration of the outer retina.25 This evidence concerns the gene CRB1 and retinitis pigmentosa 1.