The Kaplan-Meier method and Cox proportional hazards regressions models were used to determine the association of <i>MGMT</i> with OS.<h4>Results</h4>We identified 1,514 patients who were newly diagnosed with IDH-wildtype (n = 802, 33% methylated) or - mutant astrocytomas (n = 712, 48% methylated) and received chemotherapy during initial management. The gene discussed is MGMT; the disease is astrocytoma (excluding glioblastoma).