Given that the prognostic and predictive role of <i>MGMT</i> status for grade 2-3 gliomas is unresolved, we determined the effect of <i>MGMT</i> status on OS in patients with 1p19q-intact gliomas in the National Cancer Database (NCDB).<h4>Methods</h4>We queried the NCDB from 2018-2019 for patients with IDH-wildtype or -mutant astrocytomas who received chemotherapy with follow-up through 2022. Here, MGMT is linked to central nervous system cancer.