ANXA11 and sarcoidosis: Moreover, white matter has been shown to be particularly vulnerable to inflammation and microglia are the major immune effector cell within the central nervous system.50 Thus, with the association of ANXA11 with sarcoid—a systemic autoimmune condition, our multiomic findings suggest that microglial ANXA11 contributes to disease and immune dysregulation, reflecting the importance of disease-relevant cellular models.