APOE and neurodegenerative disease: There is growing recognition of the role of inflammation and immune dysregulation in neurodegeneration, including the development of a pro-inflammatory milieu in the central nervous system.45 Genes implicated in both monogenic neurodegenerative disease as well as risk genes are related to microglia and immune pathways, such as APOE, TREM2, and TBK1, and many of which were also identified in our microglial transcriptomic and proteomic data.