<h4>Background</h4>Accurate diagnosis and timely treatment are crucial in combating malaria.<h4>Methods</h4>We evaluated the diagnostic performance of three Rapid Diagnostic Tests (RDTs) in diagnosing febrile patients, namely: Abbott NxTek Eliminate Malaria Ag Pf (detecting HRP2), Rapigen Biocredit Malaria Ag Pf (detecting HRP2 and LDH on separate bands), and SD Bioline Malaria Ag Pf (detecting HRP2). Here, HDGFL2 is linked to malaria.