DUOX2 and inflammatory bowel disease: Decreased expression of Duox2 in HFDs suggests a lower inflammatory response compared to the control diet 75, which could be beneficial in halting the progression of colorectal cancer 76, and reduced expression of Ripk3 (receptor-interacting protein (RIP) family of serine/threonine protein kinases) in the terminal ileum may help alleviate inflammation in IBD 77.