HNF4a, down regulated by PL + CO in the duodenum, binds LA and plays a critical role in maintaining intestinal health, intestinal epithelial differentiation and barrier function 62–64; it is also dysregulated in colon cancer as well as colitis and is an IBD susceptibility gene 4,65,66. The gene discussed is HNF4A; the disease is malignant colon neoplasm.