PSEN2 and Alzheimer disease: A deletion (chr1:226827423–226834076, near PSEN2) spanning the entire lnc-PSEN2–7 and overlapping with a possible enhancer supported by H3K27ac signals (Fig. S9) was identified in an individual (Latin American ancestry, inferred by GRAF-pop37), who had onset of AD symptoms at age 71 years old.