TMEM106B and Alzheimer disease: A 323 bp (chr7:12242077–12242399) Alu deletion located on the exon 8 of TMEM106B is in LD with TMEM106B intronic variants, rs5011436 (chr7:12229132, R2 = 0.92)9 and rs13237518 (chr7:12229967, R2 = 0.90)10, which are not only associated with the risk of AD but also protect carriers of C9ORF72 repeat expansion from the risk of frontotemporal dementia40.