A 323 bp (chr7:12242077–12242399) Alu deletion located on the exon 8 of TMEM106B is in LD with TMEM106B intronic variants, rs5011436 (chr7:12229132, R2 = 0.92)9 and rs13237518 (chr7:12229967, R2 = 0.90)10, which are not only associated with the risk of AD but also protect carriers of C9ORF72 repeat expansion from the risk of frontotemporal dementia40. This evidence concerns the gene C9orf72 and Alzheimer disease.