Understanding the role of intestinal dysbiosis and TGF-β/AhR signaling pathways in the context of alcohol-associated pneumonia may foster novel prophylactic strategies (i.e., indole treatment) for the prevention of alcohol-associated pneumonia in high-risk individuals, which could be especially impactful for individuals with limited resources and access to alcohol treatment centers. This evidence concerns the gene TGFB1 and susceptibility to pneumonia measurement.