FOXO1 and Hyperglycemia: Chronic iAs exposure increased the gene expression of PEPCK (phosphoenolpyruvate carboxykinase) and G6PC1 (glucose-6-phosphatase), two key gluconeogenic enzymes that promote hepatic glucose synthesis and thus contribute to hyperglycemia, via prolonged activation of the transcription factor FOXO1 (forkhead box O1) [170].