It has been shown that GFAP splice variant isoform ratios modulate glioma cell invasion, cytoskeleton dynamic, and organization (Moeton et al., 2016; Stassen et al., 2017; van Bodegraven et al., 2019c; Uceda-Castro et al., 2022; van Asperen et al., 2022), suggesting that GFAP is not only a passive viewer in GBM but could also play an active role and highlight the correlation between GFAP and cytoskeleton remodeling in GBM cells. Here, GFAP is linked to glioblastoma.