Although negative GNAS mutation (16.6%, 1/6) had been reported in liver tissues from other MAS patients with cholestasis (4) (these MAS patients were not included in our review due to lack of detailed information about cholestasis), 100% (10/10) of liver tissues from the studied MAS infants with cholestasis were retrospectively detected with positive GNAS mutations. Here, GNAS is linked to cholestasis.