However, in the present study the genes (NOTCH1, CD44, BMI1, and TP53) weresignificantly expressed in T-stages, 1-2 and 3-4 of cancer showing that in earlier stages also they can be highly expressed;similarly in the present study both HPV positive and HPV negative cases did not show any significant difference in all the genesstudied, showing that HPV may not be expressed for the OSCC. The gene discussed is CD44; the disease is cancer.