Molecular changes in HNSCCmay potentially encode key signalling molecules like TP53, NOTCH1, CDKN2A, PIK3CA, HRAS, and PTEN genes [15].However, no statistically significant differences were detected in the age and gender concerning NOTCH1 mutations in T-cell acutelymphoblastic leukaemia (T-ALL) patients [16]. This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.