These receptors have been recognized as a critical regulator of various cellular processes involved in the pathogenesisof diabetes, obesity, and related cardiovascular disorders [4,5].The PPAR gene family comprises three genes that encode four unique proteins: PPARα, PPARδ, PPARγ1, and PPARγ2 [6]. This evidence concerns the gene PPARA and obesity due to melanocortin 4 receptor deficiency.