HLA class I loss is common in CC and is caused mostly by genetic abnormalitiesin the 6p21.3 locus, the non-classical HLA-G appears to be one of the most effective molecules for suppressing the innate and/oradaptive immune response by diverse immune system pathways, among other techniques adopted by tumor cells to escape identificationby different immune effectors [13]. The gene discussed is HLA-G; the disease is neoplasm.