HLA-G has been shown to suppress CD8+ T cell cytotoxicity,as well as NK cell cytotoxicity and T-cell alloproliferation also several studies have found that HLA-G expression in cancerpatients relates to tumor growth and may be a therapeutic target, it has also the potential to modify and change cytokine productionfrom a T-helper Th1 to a Th2 profile [13]. The gene discussed is CD8A; the disease is neoplasm.