Furthermore, the inhibition of p38 MAPK also abolished the radiation-induced expressions of EMT marker proteins, indicating that H2S/CSE promoted long-term metastasis of HCC cells after irradiation through promoting EMT by activating the p38 MAPK pathway, therefore inducing the invasion and metastasis of HCC cells and the xenograft tumors (Zhang et al., 2018). The gene discussed is CTH; the disease is hepatocellular carcinoma.