It can be seen from the above that several signal pathways, including EGFR/ERK/MMP-2 pathway, STAT3-COX-2 pathway, PI3K/AKT/mTOR pathway, PTEN/AKT signaling pathway, p38 MAPK pathway and AKT/FOXO3a/Rb pathway, participate in the role and mechanism of H2S in HCC. This evidence concerns the gene FOXO3 and hepatocellular carcinoma.