NR1H3 and hepatocellular carcinoma: Collectively, it could be deduced that exogenous H2S reversed doxorubicin resistance of HCC through inhibiting the levels of ABCA1 and ABCG8 by inhibiting the binding of LXRα/RXRβ with ABCG8 and ABCA1 genes promoter via suppression of the heterodimer formation between RXRβ and LXRα, which needed to be further confirmed (Stokes et al., 2018).