PNPLA2 and fatty liver disease: In addition, the modulator MFGE8, one of the cytosolic burial signals, promotes enterocyte triglyceride hydrolase activity, reduces postprandial lipids, decreases lipid accumulation in enterocytes, and ameliorates hepatic steatosis and inflammation (Khalifeh-Soltani et al., 2016; Zhang et al., 2021).