TYR and melanoma: Testing Salvia hispanica (chia) seed extract and P. granatum fruit extract (20% punicalagin), in combination or alone; Melanin inhibition assay: Melan-a cells, positive control=phenylthiourea 60 μg/ml; Tyrosinase enzyme assay: enzyme extracted from B16 melanoma cells, positive control=kojic acid; Melanogenesis-related gene expression (RT-PCR) analysis: Melan-a cells, positive control=ascorbic acid-2-glucoside