TRPA1 and Peripheral demyelination: It has been indicated that knockout of the TRPA1 gene leads to a reduction in adult oligodendrocyte apoptosis in CPZ-induced demyelination mice (19, 20), thus it can be concluded that astrocytic TRPA1 has a role in the regulation of apoptosis via Bak expression, pathways of mitogen-activated protein kinase (MAPK), and transcription factor c-Jun (21, 22).