The present study aimed to investigate the effects of 8 weeks of HIIT on the PGC1α-Keap1-Nrf2 signaling pathway, the Bax/Bcl2 ratio, and the levels of anti-oxidant enzymes (i.e., SOD, CAT, GPX) in the hippocampus of male rats with T2D. Here, PPARGC1A is linked to type 2 diabetes mellitus.