CD8A and infection: When we further focused on the separate subgroups of IGRA-positive individuals, CD4 and CD8 T cell clusters C11 and innate cell cluster C7 all were significantly increased in Group 5 (seropositive, convalescent from symptomatic infection), while CD4 T cell cluster C12 and innate cell cluster C19 were highest in Group 3 individuals (seropositive, asymptomatic) (Figure 8).