Pemphigus is a group of chronic, rare, potentially life-threatening AIBD of the skin and/or mucous membranes characterized most commonly by autoimmunity against desmoglein (DSG) proteins, namely, DSG3 alone, DSG1 alone, or both DSG3/DSG1, but other antibodies may be involved in immunization (2). The gene discussed is DSG3; the disease is pemphigus.