Analysis of BDCA2- and BDCA4-expressing pDCs revealed that the proportion of BDCA2+ pDCs was comparable before and after LVAD implantation (pre-LVAD: p = 0.40; 1st FU: p = 0.06; 2nd FU: p = 0.50; 3rd FU: p = 0.24), while the proportion of BDCA4+ pDCs decreased significantly in pre-obese (pnormal-weight vs. pre-obesity = 0.01) and obese patients (pnormal-weight vs. obesity = 0.05) at 1st FU after LVAD implantation compared to normal-weight patients, but recovered at 2nd FU (p = 0.45) and 3rd FU (p = 0.73) of LVAD support (Table 3). This evidence concerns the gene NRP1 and obesity due to melanocortin 4 receptor deficiency.