At the 3rd FU after LVAD implantation, obese patients (31.8 ± 8.5%) had a significantly lower proportion of CD8+ T cells than normal-weight patients (42.4 ± 14.2%; pnormal-weight vs. obesity = 0.04) (Figure 1B). The gene discussed is CD8A; the disease is obesity due to melanocortin 4 receptor deficiency.