Also, we documented that PTX3 interacts with FHL-1 (a truncated form of fH that comprises complement control proteins, CCPs, 1-7 and retains the ability to inhibit the AP), and this interaction is affected by the Y402H polymorphism (a major AMD-associated allele that maps in CCP7 and is thus present both in fH and FHL-1) (61). Here, FHL1 is linked to age-related macular degeneration.