In siliconsilicon analysis, we investigated the binding free energy (ΔG) of Neuropilins, an anti-cancer therapy targeting angiogenesis through the inhibition of vascular endothelial growth factor (VEGF), with various signaling pathways including CDK4, EGFR, RAS, BRAF, PI3K, and PTEN. The gene discussed is VEGFA; the disease is cancer.