BCAT1 and glioblastoma: Expression of Forkhead box protein M1 (FOXM1), a downstream target of HIF-1α39 that has been shown to play multiple roles in glioblastoma,40–44 was downregulated following BCAT1 knockdown (Figure 6A–B) and this was accompanied by downregulated expression of its target genes (Figure 6C–D).