In addition to promoting cell proliferation, FOXM1 has been implicated in maintaining a stem-like phenotype and the tumorigenicity of glioblastoma cells.40,43,45,46 BCAT1 knockdown in A11 cells reduced their capacity to form tumor spheroids and resulted in a significantly reduced frequency of cells with self-renewal capacity (Figure 6E–G). Here, BCAT1 is linked to glioblastoma.