Notably, WD + STZ mice exhibited a higher derangement in GLS following STZ injection, which may indicate additional disease pathologies resulting from compromised insulin secretion affecting glucose homeostasis, such as diabetic cardiomyopathy and cardiac autonomic neuropathy, which remain poorly understood (Nakamura et al., 2022; Sudo et al., 2022). The gene discussed is INS; the disease is diabetic cardiomyopathy.