VEGFA and periodontal disorder: Melatonin also simultaneously promotes new bone regeneration by enhancing the proliferation, migration, chondrogenic and osteogenic differentiation of mesenchymal stem cells, along with the action of increasing the vascular endothelial growthfactor (VEGF) levels, enhances angiopoiesis at sites of bone resorption, leading to the promotion of healing and prevention of ischemic injuries.[16,17] As the role of melatonin asan adjunct in treating periodontal disease has gained momentum, the efficacy of systemically administered melatonin on periodontal disease outcomes are not well understood.