Web of Science, PubMed, and Scopus databases were searched by two authors independently, with no restriction on the language and year of publication, using the following key terms: (efpeglenatide) OR (glucagon-like peptide-1 receptor agonist) AND (type 2 diabetes) OR (diabetes) OR (T2DM) AND (HbA1c) OR (FSG) OR (fasting serum glucose) OR (weight) OR (bodyweight) OR (adverse events) OR (safety) OR (AE). The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.